Comparative study of specific activity of the piroctone olamine semisolid dosage form for external use

The external treatment of seborrheic dermatitis the scalp depends on withdrawal clinical symptoms and complaints patient made to doctor. At present Ukrainian dermatology has several dozen pharmacotherapeutic products in this direction, with dominating medicines ketoconazole, zinc pyrition, their combinations. They are characterized by short-term or weak effect, associated pathogenic microorganisms’ resistance against background long-term use biologically active substances which parts. One way solve problem is using drugs new highly pharmaceutical ingredients. Employees Department Technology Medications Zaporizhzhia State Medical University proposed composition a applicate semisolid dosage form pirocton olamine based complex physical-chemical, pharmacotechnological, biopharmaceutical, rheological investigations – topical ointment hydrophilic base combination resin-free naphthalene for etiotropic scalp. aim work study specific activity combined vehicle. Materials methods. As object preclinical studies used experimental containing 1 % piroctone 5 sodium carboxymethylcellulose glycerogel, providing optimum release ingredients from vehicle, appropriate placebo form. developed under conditional name “Oktonaf” was carried out evaluating its antimicrobial, anti-inflammatory, antioxidant effects given foreseeable therapeutic focus literature spectrum biological substances. anti-inflammatory action evaluated allergic contact model. reference drug cream “Psoricap” (KMP, Ukraine), long been applied dermatological practice used. Results comparative microbiological proved that composite anti-seborrheic antibacterial effect relation size growth delay zones Staphylococcus aureus Escherichia coli (gram-positive gram-negative microorganisms) slightly exceeds effective medication “Psoricap”. same time, antimycotic Candida albicans practically does not differ drug. A basis model revealed level reliably exceed efficacy Conclusions. Obtained data can predict high value practical domestic dermatology.